New Ally of Fertility to Women Over 35 Years

A genetic screening promise to increase the number of successful in vitro fertilization. The first and second biopsy polar globule is already used by a Portuguese embriologa.

A genetic screening used in countries such as Germany, Austria, Brazil, United States of America, England and Italy, in 2012, increased hope of women over 35 years to resort to medically assisted procreation (PMA) have a successful pregnancy. This is a practice that aims to reduce the risk of miscarriage during the gestation period.

This decrease occurs through the process of transfer to the uterus of embryos that have on your origin only normal oocytes and with greatest potential for nesting. Ana Catarina Brandao, a Portuguese embriologa who lives in Austria, successfully applies this technique (first and second biopsy polar gLobule) on Kinderwunsch-Clinic. Now I can share what you told us in an interview.

What is the first and second blood cell biopsy polar?

Through techniques of preimplantation genetic diagnosis (PGD) Implantatorio, used at PMA, you can prevent sex-related diseases or genetic disorders by analyzing the y chromosome. To this end, it is necessary to obtain genetic material informative enough, through the biopsy of the first and second polar cells without harming the embryo development potential. The polar cells, which are parts of the surplus eggs, contain a copy of the maternal genetic material and analysis lets you indicate if is intact or not.

What are the advantages?

Lets you prevent fertilization and egg transfer with human aneuploidy detection (with more or less chromosomes, being one of the most common Trisomy 21) in PMA patients of advanced maternal age, not endangering the proper embryonic development for extraction of embryo cells.

Since when using this technique?

The first babies to be born through this technique they’ve known each other since 1996. However, at the beginning the disadvantages of the method were unacceptable because about of 50% of the ova were damaged during technique.

Today, a new microscopy equipment allows us to avoid possible traumas during the injection of sperm, favoring by your side a more precise fertilization in order to obtain better quality embryos. In this way, increases the likelihood of a naturally healthy egg be fertilized and implanted in the womb of the mother, increasing the rates of successful pregnancy.

Some people criticize the fact that leave out the chromosomal content, classifying it as an incomplete examination.

The chromosomal abnormalities in embryos can originate both as paterna. In this method, are only investigated the female human aneuploidy detection, not including men who may be analyzed by embryo biopsy.

However, it is known that 75% of the eggs of women over 39 years have a higher probability of chromosomal abnormalities present likely to cause abortions.


Combining polar blood cell biopsy and sperm Morphological selection for micro-injection (IMSI) Intracitoplasmatica, it is possible to select only the best ova and sperm morphologically intact.

Who can do

This screening is indicated for women wearing maternity shirts:

-With more than 35 years

-Have a history of repeat abortions of unknown cause

-With failure of various treatments of medically assisted procreation

-With genetically inherited disease known or a pathological mutation

-Which have already been diagnosed human aneuploidy detection during a pregnancy, for example through prenatal diagnostic techniques (amniocentesis, cordocentese), or after examining the products of an abortion

Text: Rita Caetano with Ana Catarina Brandão (biologist and embrióloga)