Bile Stasis in the Pregnancy

Facts

  1. Bile stasis during pregnancy is a condition in which bile acid accumulates in the blood, because the secretion is inhibited
  2. This results in pronounced itching without rash, which made their debuts after 20. weeks pregnant
  3. Diagnosis is made by that doctor/midwife examines you and blood tests
  4. Treatment is medical, and the woman followed with checks until 38. week in which birth will be set in motion

What is bile stasis in the pregnancy?
In the liver produces bile acids, which are excreted through the bile ducts in the gallbladder for storage or directly into the small intestine. In the gut is the bile necessary for fat digestion. By bile stasis in pregnancy swells the liver up, because bile ducts will be partially clamped. Part of the bile penetrates into the bloodstream and thus leads to higher concentration of bile acids and bile pigments in the blood. Increased concentration of bile acids in the blood is the direct cause of the annoying itching, which is typical for this condition.

How frequent is bile stasis in the pregnancy?
About 1% of all pregnant women.

What is caused by bile stasis in the pregnancy?
This is a disease that occurs only during pregnancy. No one knows for sure what it is about the pregnancy, which trigger the condition, but assume that it may be an increased sensitivity of the high level of female sex hormone (estrogen).

In 2000-2006, the disease found at 1.1% of the pregnant women in Denmark. The disease is seen more often among Asian women.

What are the symptoms of bile stasis in the pregnancy?
Itching in the latter half of pregnancy without skin rash with no other known cause.

How made the diagnosis?
The typical course of events is that the pregnant will be bothered by severe itching. The itching is usually present in most parts of the body, but is often most intense in the palms and soles of the feet. The itching is typically worse at night. With most of the itching occurs in the latter part of pregnancy most often in 3. trimester, but with some already in 2. trimester. There seems no rash with itching, but only scratch marks. At ca. 10% can be seen slight jaundice.

By medical examination, one can differentiate this disease from others who also causes itching in pregnancy, using blood samples. It is typical that there is a much higher incidence of bile acids and specific liver samples of blood.

The disease is dangerous?
The disease is harmless to the mother, but probably a very slightly increased risk for sudden fetal death. There is also a slightly increased risk of premature birth. The disease does not give greater risk of congenital malformations in the child.

The itching will disappear and blood samples will be normal a few days after birth.

What treatment is there?
It is recommended to treat women with this condition with medication, which lowers the level of bile acids in the blood (ursodeoxycholic acid). It is shown that the treatment causes the itching is reduced, and blood samples will be better, but we have not been able to identify with certainty a decrease in risk of sudden foetal death. The medicine is safe for both mother and child.

Mothers with this disease will be offered extra monitoring and fetal monitoring. Taking blood tests on the mother, and monitor the baby’s heart beat once a week. The birth be as a general rule, started at the full 38. weeks, since the risk of sudden fetal death is highest in the last weeks of pregnancy. See all acronyms here.

How do I avoid getting or exacerbating bile stasis in the pregnancy?
There is no evidence that it can prevent bile stasis in the pregnancy.

If treatment with ursodeoxycholic acid is launched, and the itching increases, you should contact your doctor so that the dose of the medication can be increased.

Gallery

Role of serum Bile acids in Intrahepatic Cholestasis of …

Role of serum Bile acids in Intrahepatic Cholestasis of ...

Source: www.slideshare.net

Role of serum Bile acids in Intrahepatic Cholestasis of …

Role of serum Bile acids in Intrahepatic Cholestasis of ...

Source: www.slideshare.net

Cholestasis. Causes, symptoms, treatment Cholestasis

Cholestasis. Causes, symptoms, treatment Cholestasis

Source: dxline.info

6 gall blader & biliary tree diseases

6 gall blader & biliary tree diseases

Source: www.slideshare.net

Cholestasis as related to Pregnancy

Cholestasis as related to Pregnancy

Source: www.goldbamboo.com

Emmet Andrews Cork University Hospital 6th September ppt …

Emmet Andrews Cork University Hospital 6th September ppt ...

Source: slideplayer.com

Stillbirth & Obstetric Cholestasis

Stillbirth & Obstetric Cholestasis

Source: www.action.org.uk

Cholecystitis Pathophysiology & Schematic Diagram

Cholecystitis Pathophysiology & Schematic Diagram

Source: www.scribd.com

Histo/Path: Liver at Columbia College of Physicians …

Histo/Path: Liver at Columbia College of Physicians ...

Source: www.studyblue.com

Histo/Path: Liver at Columbia College of Physicians …

Histo/Path: Liver at Columbia College of Physicians ...

Source: studyblue.com

Gallbladder Disorders

Gallbladder Disorders

Source: slideplayer.com

Understanding Gallstone Disease

Understanding Gallstone Disease

Source: www.pharmacytimes.com

02. Purulent-inflammatory diseases of abdominal cavity

02. Purulent-inflammatory diseases of abdominal cavity

Source: intranet.tdmu.edu.ua

Intrahepatic cholestasis of pregnancy

Intrahepatic cholestasis of pregnancy

Source: es.slideshare.net

Gallbladder, Extrahepatic Biliary Tree, and Ampulla …

Gallbladder, Extrahepatic Biliary Tree, and Ampulla ...

Source: basicmedicalkey.com

Patologias hepaticas GENERALIDADES: -ubicacion, peso …

Patologias hepaticas GENERALIDADES: -ubicacion, peso ...

Source: slideplayer.es

Role of serum Bile acids in Intrahepatic Cholestasis of …

Role of serum Bile acids in Intrahepatic Cholestasis of ...

Source: es.slideshare.net

Cholestasis Of Pregnancy, Causes Symptoms and Treatment …

Cholestasis Of Pregnancy, Causes Symptoms and Treatment ...

Source: infobaby.org

What is Cholestasis of Pregnancy or Obstetric Cholestasis?

What is Cholestasis of Pregnancy or Obstetric Cholestasis?

Source: www.epainassist.com

Emmet Andrews Cork University Hospital 6th September ppt …

Emmet Andrews Cork University Hospital 6th September ppt ...

Source: slideplayer.com